• HT-29-MTX-E12甲氨蝶呤诱导HT29细胞分化为成熟杯状细胞(STR鉴定正确)

    价 格🈚️:¥3000

    期 货🚺:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号🏏:BTCC-1342

    产地:中国

    套 餐:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameHT-29-MTX-E12
    SynonymsHT29-MTX-E12; MTX-E12
    AccessionBTCC-1342
    Resource Identification InitiativeTo cite this cell line use: HT-29-MTX-E12 (BTCC-1342)
    CommentsPopulation: Caucasian.
    Selected for resistance to: ChEBI; CHEBI:44185; Methotrexate (MTX).
    Derived from site: In situ; Colon; UBERON=UBERON_0001155.
    Sequence variations
    • Mutation; HGNC; 583; APC; Simple; p.Glu853Ter (c.2557G>T); ClinVar=VCV001071632; Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 583; APC; Simple; p.Thr1556Asnfs*3 (c.4666dupA) (c.4666_4667insA); ClinVar=VCV000428112; Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 8975; PIK3CA; Simple; p.Pro449Thr (c.1345C>A); ClinVar=VCV001333250; Zygosity=Heterozygous (from parent cell line).
    • Mutation; HGNC; 6770; SMAD4; Simple; p.Gln311Ter (c.931C>T); ClinVar=VCV000230663; Zygosity=Homozygous (from parent cell line).
    • Mutation; HGNC; 11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Homozygous (from parent cell line).
    DiseaseColon adenocarcinoma (NCIt: C4349)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyParent: CVCL_6834 (HT-29-MTX)
    Sex of cellFemale
    Age at sampling44Y
    CategoryCancer cell line
    STR profileSource(s): ECACC

    Markers:
    AmelogeninX
    CSF1PO11,12
    D5S81811,12
    D7S82010
    D13S31711
    D16S53911,12
    TH016
    TPOX8,9
    vWA17

    Run an STR similarity search on this cell line
    Publications

    PubMed=11587485; DOI=10.1023/A:1010974909998
    Behrens I., Stenberg P., Artursson P., Kissel T.
    Transport of lipophilic drug molecules in a new mucus-secreting cell culture model based on HT29-MTX cells.
    Pharm. Res. 18:1138-1145(2001)

    Cross-references
    Cell line collections (Providers)ECACC; 12040401
    Encyclopedic resourcesWikidata; Q54896519

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