• Daoy人髓母细胞瘤细胞(STR鉴定正确)

    价 格:¥1800

    期 货🔙:现货(冻存管发2支)

    保藏中心🔘:BTCC

    资源编号:BTCC-1224

    产地:中国

    套 餐☕️:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameDaoy
    SynonymsDAOY; D324 Med; D-324 Med; D324 MED; D-324MED; D324
    AccessionBTCC-1224
    Secondary accessionBTCC-1224
    Resource Identification InitiativeTo cite this cell line use: Daoy (BTCC-1224)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Population: Caucasian.
    Doubling time: 33.6 hours (Note=At 48th passage) (PubMed=2993532); 32 +- 1.5 hours (PubMed=31346954); 34 hours (ATCC=HTB-186).
    Microsatellite instability: Stable (MSS) (Sanger).
    Omics: Deep exome analysis.
    Omics: Deep quantitative proteome analysis.
    Omics: DNA methylation analysis.
    Omics: Proteome analysis by 2D-DE/MS.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Derived from site: In situ; Brain, cerebellum; UBERON=UBERON_0002037.
    Sequence variations
    • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (ATCC).
    • Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=31068700).
    • Mutation; HGNC; 11998; TP53; Simple; p.Cys242Phe (c.725G>T); ClinVar=VCV000376578; Zygosity=Homozygous (PubMed=22343310; ATCC; Cosmic-CLP; DepMap).
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African0.45
    Native American0
    East Asian, North1.54
    East Asian, South0
    South Asian1.1
    European, North64.36
    European, South32.54
    DiseaseMedulloblastoma, SHH-activated, TP53-mutant (NCIt: C129442)
    Medulloblastoma (ORDO: Orphanet_616)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    Sex of cellMale
    Age at sampling4Y
    CategoryCancer cell line
    STR profileSource(s): ATCC; CCRID; Cosmic-CLP; PubMed=25877200

    Markers:
    AmelogeninX
    CSF1PO11
    D2S133816,17
    D3S135815
    D5S81811,13
    D7S8208,10
    D8S117913,15
    D13S31713,14
    D16S53910
    D18S5112
    D19S43314,14.2 (CCRID)
    14.2 (PubMed=25877200)
    D21S1129,31.2
    FGA23
    Penta D10,13
    Penta E7,11
    TH019
    TPOX8,10
    vWA14,20

    Run an STR similarity search on this cell line
    Web pageshttps://en.wikipedia.org/wiki/DAOY_(biology)
    https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/d/cell-lines-detail-566.html
    Publications

    PubMed=2993532; DOI=10.1097/00005072-198509000-00003
    Jacobsen P.F., Jenkyn D.J., Papadimitriou J.M.
    Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice.
    J. Neuropathol. Exp. Neurol. 44:472-485(1985)

    PubMed=1822845
    Wikstrand C.J., Friedman H.S., Bigner D.D.
    Medulloblastoma cell-substrate interaction in vitro.
    Invasion Metastasis 11:310-324(1991)

    DOI=10.1016/B978-0-12-333530-2.50005-8
    Nister M., Westermark B.
    Human glioma cell lines.
    (In) Atlas of human tumor cell lines; Hay R.J., Park J.-G., Gazdar A.F. (eds.); pp.17-42; Academic Press; New York (1994)

    DOI=10.1007/0-306-46861-1_11
    Ali-Osman F.
    Brain tumors.
    (In) Human cell culture. Vol. 2. Cancer Cell Lines part 2; Masters J.R.W., Palsson B.O. (eds.); pp.167-184; Kluwer Academic Publishers; New York (1999)

    PubMed=12973738; DOI=10.1002/pmic.200300460
    Peyrl A., Krapfenbauer K., Slavc I., Yang J.-W., Strobel T., Lubec G.
    Protein profiles of medulloblastoma cell lines DAOY and D283: identification of tumor-related proteins and principles.
    Proteomics 3:1781-1800(2003)

    PubMed=18773455; DOI=10.1002/cyto.a.20633
    Srivastava V.K., Nalbantoglu J.
    Flow cytometric characterization of the DAOY medulloblastoma cell line for the cancer stem-like phenotype.
    Cytometry A 73:940-948(2008)

    PubMed=20164919; DOI=10.1038/nature08768
    Bignell G.R., Greenman C.D., Davies H., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
    Signatures of mutation and selection in the cancer genome.
    Nature 463:893-898(2010)

    PubMed=20847082; DOI=10.1093/neuonc/noq091
    Teider N., Scott D.K., Neiss A., Weeraratne S.D., Amani V.M., Wang Y., Marquez V.E., Cho Y.-J., Pomeroy S.L.
    Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.
    Neuro-oncol. 12:1244-1256(2010)

    PubMed=22343310; DOI=10.1016/j.neulet.2012.02.022
    Ghassemifar S., Mendrysa S.M.
    MDM2 antagonism by nutlin-3 induces death in human medulloblastoma cells.
    Neurosci. Lett. 513:106-110(2012)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=22723427; DOI=10.1093/neuonc/nos130
    Sikkema A.H., den Dunnen W.F.A., Hulleman E., van Vuurden D.G., Garcia-Manero G., Yang H., Scherpen F.J.G., Kampen K.R., Hoving E.W., Kamps W.A., Diks S.H., Peppelenbosch M.P., de Bont E.S.J.M.
    EphB2 activity plays a pivotal role in pediatric medulloblastoma cell adhesion and invasion.
    Neuro-oncol. 14:1125-1135(2012)

    PubMed=24297863; DOI=10.1158/1078-0432.CCR-13-2281
    Bandopadhayay P., Bergthold G., Nguyen B., Schubert S., Gholamin S., Tang Y.-J., Bolin S., Schumacher S.E., Zeid R., Masoud S., Yu F.-R., Vue N., Gibson W.J., Paolella B.R., Mitra S.S., Cheshier S.H., Qi J., Liu K.-W., Wechsler-Reya R.J., Weiss W.A., Swartling F.J., Kieran M.W., Bradner J.E., Beroukhim R., Cho Y.-J.
    BET bromodomain inhibition of MYC-amplified medulloblastoma.
    Clin. Cancer Res. 20:912-925(2014)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=27498314; DOI=10.1016/j.jbiotec.2016.07.028
    Ivanov D.P., Coyle B., Walker D.A., Grabowska A.M.
    In vitro models of medulloblastoma: choosing the right tool for the job.
    J. Biotechnol. 236:10-25(2016)

    PubMed=27812533; DOI=10.1016/j.dib.2016.10.004
    Ivanov D.P., Walker D.A., Coyle B., Grabowska A.M.
    Data on the number and frequency of scientific literature citations for established medulloblastoma cell lines.
    Data Brief 9:696-698(2016)

    PubMed=29900115; DOI=10.1016/j.euprot.2016.03.015
    Martelli C., D'Angelo L., Barba M., Baranzini M., Inserra I., Iavarone F., Vincenzoni F., Tamburrini G., Massimi L., Di Rocco C., Caldarelli M., Messana I., Michetti F., Castagnola M., Lattanzi W., Desiderio C.
    Top-down proteomic characterization of DAOY medulloblastoma tumor cell line.
    EuPA Open Proteomics 12:13-21(2016)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=31346954; DOI=10.1007/s10616-019-00332-3
    Bonfim Silva R., Salomao K.B., de Andrade Pimentel T.V.C., de Oliveira Menezes C.C.B., Palma P.V.B., Fontes A.M.
    Biological characterization of the UW402, UW473, ONS-76 and DAOY pediatric medulloblastoma cell lines.
    Cytotechnology 71:893-903(2019)

    PubMed=31963405; DOI=10.3390/cancers12010226
    Casciati A., Tanori M., Manczak R., Saada S., Tanno B., Giardullo P., Porcu E., Rampazzo E., Persano L., Viola G., Dalmay C., Lalloue F., Pothier A., Merla C., Mancuso M.
    Human medulloblastoma cell lines: investigating on cancer stem cell-like phenotype.
    Cancers (Basel) 12:226.1-226.14(2020)

    PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
    Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
    Quantitative proteomics of the Cancer Cell Line Encyclopedia.
    Cell 180:387-402.e16(2020)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0002699
    CCRID; 1101HUM-PUMC000218
    CCRID; 3101HUMSCSP509
    Cell_Model_Passport; SIDM00887
    Cosmic-CLP; 906833
    DepMap; ACH-000211
    LINCS_LDP; LCL-1576
    Lonza; 1438
    Anatomy/cell type resourcesBTO; BTO:0004328
    Biological sample resourcesBioSample; SAMN03470909
    BioSample; SAMN10988097
    ENCODE; ENCBS055ILX
    ENCODE; ENCBS812KQP
    Cell line collections (Providers)ATCC; HTB-186
    BCRJ; 0325
    CLS; 305053
    KCB; KCB 2010203YJ
    NCBI_Iran; C519
    Chemistry resourcesChEMBL-Cells; CHEMBL3308510
    ChEMBL-Targets; CHEMBL612519
    GDSC; 906833
    PharmacoDB; Daoy_282_2019
    PubChem_Cell_line; CVCL_1167
    Encyclopedic resourcesWikidata; Q29511023
    Experimental variables resourcesEFO; EFO_0005698

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