• EoL-1人急性髓系白血病细胞(STR鉴定正确)

    价 格🏃🏻‍♂️‍➡️:¥3000

    期 货👩‍🦯𓀐:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号:BTCC-1427

    产地👳🏼‍♀️:中国

    套 餐🧇:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameEoL-1
    SynonymsEOL-1; EOL1; EoL-1-cell; EoL-1 cell; AML-EOL-1
    AccessionBTCC-1427
    Resource Identification InitiativeTo cite this cell line use: EoL-1 (BTCC-1427)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Part of: LL-100 blood cancer cell line panel.
    Population: Caucasian.
    Doubling time: ~60 hours (DSMZ=ACC-386).
    Microsatellite instability: Stable (MSS) (Sanger).
    Omics: Genomics; DNA methylation analysis.
    Omics: Genomics; Whole exome sequencing.
    Omics: Phenotyping; Drug screening.
    Omics: Proteomics; Quantitative.
    Omics: Transcriptomics; Microarray.
    Omics: Transcriptomics; RNAseq.
    Omics: Variations; SNP array analysis.
    Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
    Sequence variations
    HLA typingSource: PubMed=26589293
    Class I
    HLA-AA*24:02,29:02
    HLA-BB*35:03,44:03
    HLA-CC*04:01,16:01

    Source: DSMZCellDive=ACC-386
    Class I
    HLA-AA*24:02:01,29:02:01
    HLA-BB*35:03:01,44:03:01
    HLA-CC*04:01:01,16:01:01
    Class II
    HLA-DPDPA1*01:03:01,01:03:01

    DPB1*02:01:02,02:01:02
    HLA-DQDQA1*03:03:01,03:03:01

    DQB1*03:01:01,03:01:01
    HLA-DRDRA*01:01:01,01:02:02

    DRB1*04:07:01,12:01:01
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African1.14
    Native American0
    East Asian, North2.93
    East Asian, South0
    South Asian0
    European, North52.17
    European, South43.75
    DiseaseChronic eosinophilic leukemia, not otherwise specified (NCIt: C4563)
    Chronic eosinophilic leukemia (ORDO: Orphanet_168940)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    Originate from same individualCVCL_S960 ! EoL-2
    CVCL_4069 ! EoL-3
    Sex of cellMale
    Age at sampling33Y
    CategoryCancer cell line
    STR profileSource(s): Cosmic-CLP=906856; DSMZ=ACC-386; ECACC=94042252; PubMed=25877200; RCB=RCB0641; TKG=TKG 0476

    Markers:
    AmelogeninX,Y
    CSF1PO7,10
    D2S133817,18
    D3S135816,17
    D5S81811
    D7S82010,13
    D8S117913
    D13S31712,13
    D16S5398,10
    D18S5112,14
    D19S43312,13
    D21S1129
    FGA24
    Penta D7,10,11 (DSMZ=ACC-386)
    7,11 (PubMed=25877200)
    Penta E5,7
    TH019.3
    TPOX8
    vWA16,17

    Run an STR similarity search on this cell line
    Publications

    PubMed=2415185; DOI=10.1182/blood.V66.6.1233.1233
    Saito H., Bourinbaiar A.S., Ginsburg M., Minato K., Ceresi E., Yamada K., Machover D., Breard J., Mathe G.
    Establishment and characterization of a new human eosinophilic leukemia cell line.
    Blood 66:1233-1240(1985)

    PubMed=1477652; DOI=10.3109/10428199209053629
    Mayumi M.
    EoL-1, a human eosinophilic cell line.
    Leuk. Lymphoma 7:243-250(1992)

    DOI=10.11418/jtca1981.15.4_211
    Matsuo Y., Okochi A., Ariyasu T., Iimura E., Ohno T.
    Identification of cell lines with variable numbers of tandem repeat (VNTR) amplified by polymerase chain reaction.
    Tissue Cult. Res. Commun. 15:211-219(1996)

    PubMed=8558913
    Morita S., Tsuchiya S., Fujie H., Itano M., Ohashi Y., Minegishi M., Imaizumi M., Endo M., Takano N., Konno T.
    Cell surface c-kit receptors in human leukemia cell lines and pediatric leukemia: selective preservation of c-kit expression on megakaryoblastic cell lines during adaptation to in vitro culture.
    Leukemia 10:102-105(1996)

    DOI=10.1016/B978-0-12-221970-2.50457-5
    Drexler H.G.
    The leukemia-lymphoma cell line factsbook.
    (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

    PubMed=14630792; DOI=10.1182/blood-2003-07-2479
    Cools J., Quentmeier H., Huntly B.J.P., Marynen P., Griffin J.D., Drexler H.G., Gilliland D.G.
    The EOL-1 cell line as an in vitro model for the study of FIP1L1-PDGFRA-positive chronic eosinophilic leukemia.
    Blood 103:2802-2805(2004)

    PubMed=14671638; DOI=10.1038/sj.leu.2403236
    Drexler H.G., Quentmeier H., MacLeod R.A.F.
    Malignant hematopoietic cell lines: in vitro models for the study of MLL gene alterations.
    Leukemia 18:227-232(2004)

    PubMed=15843827; DOI=10.1038/sj.leu.2403749
    Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
    Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
    Leukemia 19:1042-1050(2005)

    PubMed=16408098; DOI=10.1038/sj.leu.2404081
    Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
    JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
    Leukemia 20:471-476(2006)

    PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
    Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
    Signatures of mutation and selection in the cancer genome.
    Nature 463:893-898(2010)

    PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=25877200; DOI=10.1038/nature14397
    Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
    A resource for cell line authentication, annotation and quality control.
    Nature 520:307-311(2015)

    PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
    Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
    TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
    Genome Med. 7:118.1-118.7(2015)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=30285677; DOI=10.1186/s12885-018-4840-5; PMCID=PMC6167786
    Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H.H., Koeffler H.P.
    Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
    BMC Cancer 18:940.1-940.13(2018)

    PubMed=30629668; DOI=10.1371/journal.pone.0210404; PMCID=PMC6328144
    Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
    Screening human cell lines for viral infections applying RNA-Seq data analysis.
    PLoS ONE 14:e0210404.1-e0210404.22(2019)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646
    Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K.G., Uphoff C.C., Drexler H.G.
    The LL-100 panel: 100 cell lines for blood cancer studies.
    Sci. Rep. 9:8218.1-8218.14(2019)

    PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
    Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. 3rd, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
    Quantitative proteomics of the Cancer Cell Line Encyclopedia.
    Cell 180:387-402.e16(2020)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line collections (Providers)DSMZ; ACC-386
    ECACC; 94042252
    RCB; RCB0641
    RCB; RCB3679 - Discontinued
    TKG; TKG 0476
    Cell line databases/resourcesCLO; CLO_0002932
    CLO; CLO_0002933
    CLO; CLO_0050996
    MCCL; MCC:0000149
    CLDB; cl1166
    cancercelllines; CVCL_0258
    Cell_Model_Passport; SIDM00277
    Cosmic-CLP; 906856
    DepMap; ACH-000198
    DSMZCellDive; ACC-386
    Anatomy/cell type resourcesBTO; BTO_0002405
    Biological sample resourcesBioSample; SAMN01821624
    BioSample; SAMN03473158
    BioSample; SAMN10988490
    CRISP screens repositoriesBioGRID_ORCS_Cell_line; 209
    Chemistry resourcesChEMBL-Cells; CHEMBL3308381
    ChEMBL-Targets; CHEMBL614489
    GDSC; 906856
    PharmacoDB; EoL1cell_335_2019
    PubChem_Cell_line; CVCL_0258
    Encyclopedic resourcesWikidata; Q54832338
    Experimental variables resourcesEFO; EFO_0022659
    Gene expression databasesArrayExpress; E-MTAB-783
    ArrayExpress; E-MTAB-2770
    ArrayExpress; E-MTAB-3610
    ArrayExpress; E-MTAB-7721
    ArrayExpress; E-MTAB-7722
    FANTOM5_SSTAR; 10832-111D4
    GEO; GSM887006
    GEO; GSM888075
    GEO; GSM1374475
    GEO; GSM1446733
    GEO; GSM1669766

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