• NUGC-3人胃癌细胞(STR鉴定正确)

    价 格🟩:¥2400

    期 货📘:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号:BTCC-1423

    产地:中国

    套 餐👨🏿‍💼5️⃣:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameNUGC-3
    SynonymsNUGC3; NU-GC-3; Nagoya University-Gastric Cancer-3
    AccessionBTCC-1423
    Secondary accession
    Resource Identification InitiativeTo cite this cell line use: NUGC-3 (BTCC-1423)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Part of: JFCR45 cancer cell line panel.
    Part of: MD Anderson Cell Lines Project.
    Population: Japanese.
    Doubling time: 38.2 hours (PubMed=3172586); 29 hours (PubMed=29435981); ~26 hours (Note=Lot 06062005), 28-45 hours (Note=Lot 04272009), ~32 hours (Note=Lot 11042011), ~28 hours (Note=Lot 02262016), ~1 day (Note=Lot 11162017) (JCRB=JCRB0822).
    Microsatellite instability: Instable (MSI-high) (PubMed=31068700; Sanger).
    Omics: Genomics; DNA methylation analysis.
    Omics: Genomics; Whole exome sequencing.
    Omics: Phenotyping; CRISPR screening.
    Omics: Phenotyping; Drug screening.
    Omics: Proteomics; Expression; Reverse-phase protein array.
    Omics: Proteomics; Quantitative.
    Omics: Transcriptomics; Microarray.
    Omics: Transcriptomics; RNAseq.
    Omics: Variations; Array-based CGH.
    Omics: Variations; SNP array analysis.
    Misspelling: MUGC-3; Cosmic=1187288; PubMed=19132987.
    Misspelling: NVGC3; Cosmic=801341.
    Derived from site: Metastatic; Brachialis muscle; UBERON=UBERON_0001506.
    Sequence variations
    HLA typingSource: PubMed=26589293
    Class I
    HLA-AA*24:02,24:02
    HLA-BB*52:01,52:01
    HLA-CC*12:02,12:02
    Class II
    HLA-DQDQA1*05:02,05:02

    DQB1*06:01,06:01
    HLA-DRDRB1*15:02,15:02
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African0
    Native American0.09
    East Asian, North82.25
    East Asian, South16.95
    South Asian0
    European, North0
    European, South0.71
    DiseaseGastric adenocarcinoma (NCIt: C4004)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyChildren:


    CVCL_4Y07 (NUGC-3-Luc)CVCL_L502 (NUGC-3/5-FU/L)
    Sex of cellMale
    Age at sampling72Y
    CategoryCancer cell line
    STR profileSource(s): Cosmic-CLP=908455; JCRB=JCRB0822; PubMed=25877200

    Markers:
    AmelogeninX
    CSF1PO13
    D3S135816,17
    D5S81811
    D7S8208,9
    D8S117912,13,16,17
    D13S31710,11
    D16S53910,11
    D18S5118,19
    D21S1130,31
    FGA17
    Penta D11
    Penta E11,18
    TH016,8
    TPOX8,9
    vWA18

    Run an STR similarity search on this cell line
    Web pagesInfo; MCLP; -; https://tcpaportal.org/mclp/
    Publications

    PubMed=3325673; DOI=10.1007/BF02470755
    Watanabe T., Nishikimi M., Akiyama S., Sakamoto J., Shiku H., Ichihashi H., Ozawa T., Kondo T., Takagi H.
    A stomach oncofetal antigen recognized by monoclonal antibody GC302.
    Jpn. J. Surg. 17:507-516(1987)

    PubMed=3172586; DOI=10.1007/BF02471470
    Akiyama S., Amo H., Watanabe T., Matsuyama M., Sakamoto J., Imaizumi M., Ichihashi H., Kondo T., Takagi H.
    Characteristics of three human gastric cancer cell lines, NU-GC-2, NU-GC-3 and NU-GC-4.
    Jpn. J. Surg. 18:438-446(1988)

    PubMed=1778766; DOI=10.1111/j.1349-7006.1991.tb01816.x; PMCID=PMC5918361
    Takeshima E., Hamaguchi M., Watanabe T., Akiyama S., Kataoka M., Ohnishi Y., Xiao H.-Y., Nagai Y., Takagi H.
    Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells.
    Jpn. J. Cancer Res. 82:1428-1435(1991)

    PubMed=1370612; DOI=10.1016/S0006-291X(05)80133-0
    Matozaki T., Sakamoto C., Matsuda K., Suzuki T., Konda Y., Nakano O., Wada K., Uchida T., Nishisaki H., Nagao M., Kasuga M.
    Missense mutations and a deletion of the p53 gene in human gastric cancer.
    Biochem. Biophys. Res. Commun. 182:215-223(1992)

    PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::aid-mc5>3.0.CO;2-D
    Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T., Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M., Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.
    Screening the p53 status of human cell lines using a yeast functional assay.
    Mol. Carcinog. 19:243-253(1997)

    PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020
    Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H., Okanoue T., Inazawa J.
    Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.
    Cancer Sci. 96:100-110(2005)

    PubMed=15767549; DOI=10.1158/1535-7163.MCT-04-0234
    Nakatsu N., Yoshida Y., Yamazaki K., Nakamura T., Dan S., Fukui Y., Yamori T.
    Chemosensitivity profile of cancer cell lines and identification of genes determining chemosensitivity by an integrated bioinformatical approach using cDNA arrays.
    Mol. Cancer Ther. 4:399-412(2005)

    PubMed=19132987; DOI=10.1111/j.1600-0463.2008.01042.x
    Li Y.-Q., Tanaka Y., Tada M., Hua R., Seto M., Asaoka Y., Ohta M., Kanai F., Yoshida H., Kawabe T., Sano T., Motojima T., Yokosuka O., Omata M.
    Absence of the AKT1 pleckstrin homology domain mutation in Japanese gastrointestinal and liver cancer patients.
    APMIS 116:931-933(2008)

    PubMed=20164919; DOI=10.1038/nature08768; PMCID=PMC3145113
    Bignell G.R., Greenman C.D., Davies H.R., Butler A.P., Edkins S., Andrews J.M., Buck G., Chen L., Beare D., Latimer C., Widaa S., Hinton J., Fahey C., Fu B.-Y., Swamy S., Dalgliesh G.L., Teh B.T., Deloukas P., Yang F.-T., Campbell P.J., Futreal P.A., Stratton M.R.
    Signatures of mutation and selection in the cancer genome.
    Nature 463:893-898(2010)

    PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662
    Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
    A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
    Cancer Res. 70:2158-2164(2010)

    PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=24807215; DOI=10.1038/ncomms4830; PMCID=PMC4024760
    Liu J.-F., McCleland M.L., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H.-B., Wan Y.-N., Chopra V.S., Yaylaoglu M.B., Yuan W.-L., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.-M.
    Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.
    Nat. Commun. 5:3830.1-3830.8(2014)

    PubMed=25343454; DOI=10.1371/journal.pone.0111146; PMCID=PMC4208810
    Choong M.-L., Tan S.-H., Tan T.-Z., Manesh S., Ngo A., Yong J.W.-Y., Yang H.H., Lee M.A.
    Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.
    PLoS ONE 9:e111146.1-e111146.9(2014)

    PubMed=25485619; DOI=10.1038/nbt.3080
    Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
    A comprehensive transcriptional portrait of human cancer cell lines.
    Nat. Biotechnol. 33:306-312(2015)

    PubMed=25877200; DOI=10.1038/nature14397
    Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
    A resource for cell line authentication, annotation and quality control.
    Nature 520:307-311(2015)

    PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878
    Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
    TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
    Genome Med. 7:118.1-118.7(2015)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017; PMCID=PMC4967469
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005; PMCID=PMC5501076
    Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
    Characterization of human cancer cell lines by reverse-phase protein arrays.
    Cancer Cell 31:225-239(2017)

    PubMed=29435981; DOI=10.1002/ijc.31304
    Kim H.J., Kang S.K., Kwon W.S., Kim T.S., Jeong I., Jeung H.-C., Kragh M., Horak I.D., Chung H.C., Rha S.Y.
    Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.
    Int. J. Cancer 143:151-159(2018)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=30971826; DOI=10.1038/s41586-019-1103-9
    Behan F.M., Iorio F., Picco G., Goncalves E., Beaver C.M., Migliardi G., Santos R., Rao Y., Sassi F., Pinnelli M., Ansari R., Harper S., Jackson D.A., McRae R., Pooley R., Wilkinson P., van der Meer D.J., Dow D., Buser-Doepner C.A., Bertotti A., Trusolino L., Stronach E.A., Saez-Rodriguez J., Yusa K., Garnett M.J.
    Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
    Nature 568:511-516(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3; PMCID=PMC6697103
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. 3rd, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=31978347; DOI=10.1016/j.cell.2019.12.023; PMCID=PMC7339254
    Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. 3rd, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
    Quantitative proteomics of the Cancer Cell Line Encyclopedia.
    Cell 180:387-402.e16(2020)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010; PMCID=PMC9387775
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line collections (Providers)JCRB; JCRB0822
    Cell line databases/resourcesCLO; CLO_0037144
    cancercelllines; CVCL_1612
    Cell_Model_Passport; SIDM00572
    CGH-DB; 134-1
    Cosmic-CLP; 908455
    DepMap; ACH-000911
    LINCS_LDP; LCL-1887
    Anatomy/cell type resourcesBTO; BTO_0002597
    Biological sample resourcesBioSample; SAMN03473123
    BioSample; SAMN10988359
    CRISP screens repositoriesBioGRID_ORCS_Cell_line; 397
    Chemistry resourcesChEMBL-Cells; CHEMBL3307562
    ChEMBL-Targets; CHEMBL614208
    GDSC; 908455
    PharmacoDB; NUGC3_1173_2019
    PubChem_Cell_line; CVCL_1612
    Encyclopedic resourcesWikidata; Q54931160
    Experimental variables resourcesEFO; EFO_0006702

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