• REC-1人非霍奇金淋巴瘤细胞(STR鉴定正确)

    价 格👶🏿👩🏼:¥3000

    期 货:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号:BTCC-1405

    产地🔻😂:中国

    套 餐✣:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameREC-1
    SynonymsRec-1; REC 1; REC1; Rec1; rec1; REC
    AccessionBTCC-1405
    Resource Identification InitiativeTo cite this cell line use: REC-1 (RRID:CVCL_1884)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: LL-100 blood cancer cell line panel.
    Part of: Lymphoma Research Foundation Mantle Cell Lymphoma cell bank (LRF MCL cell bank).
    Part of: MD Anderson Cell Lines Project.
    Population: Caucasian.
    Doubling time: 38 hours (PubMed=25315077); ~38 hours (ATCC=CRL-3004); ~20-40 hours (DSMZ=ACC-584).
    Omics: Array-based CGH.
    Omics: Deep exome analysis.
    Omics: Deep quantitative proteome analysis.
    Omics: Protein expression by reverse-phase protein arrays.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Omics: Virome analysis using RNAseq.
    Caution: Wrongly indicated as originating from the lymph node of a 57 year old patient in ATCC.
    Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
    Sequence variations
    • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=16448697).
    • Mutation; HGNC; 11998; TP53; Simple; p.Gly245Asp (c.734G>A); ClinVar=VCV000012355; Zygosity=Heterozygous (DepMap).
    • Mutation; HGNC; 11998; TP53; Simple; p.Gln317Ter (c.949C>T); ClinVar=VCV000450344; Zygosity=Heterozygous (DepMap).
    HLA typingSource: PubMed=25960936
    Class I
    HLA-AA*26:01,36:04
    HLA-BB*35:01,57:01
    HLA-CC*04:01,06:02
    Class II
    HLA-DQDQA1*01:02,01:02
    HLA-DRDRB1*04:03,04:03

    Source: PubMed=25688540
    Class I
    HLA-AA*01,03
    HLA-BB*35,57
    HLA-CC*04,06

    Source: PubMed=26589293
    Class I
    HLA-AA*01:01,24:02
    HLA-BB*35:01,57:01
    HLA-CC*04:01,06:02
    Class II
    HLA-DQDQA1*01:02,01:02

    DQB1*03:02,03:02
    HLA-DRDRB1*01:01,01:01

    Source: DSMZCellDive=ACC-584
    Class I
    HLA-BB*35:01:01,57:01:01
    HLA-CC*04:01:01,06:02:01
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African1.88
    Native American0
    East Asian, North2.34
    East Asian, South0
    South Asian0
    European, North48.87
    European, South46.91
    DiseaseMantle cell lymphoma (NCIt: C4337)
    Mantle cell lymphoma (ORDO: Orphanet_52416)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    Sex of cellMale
    Age at sampling61Y
    CategoryCancer cell line
    STR profileSource(s): ATCC; DSMZ; PubMed=25877200

    Markers:
    AmelogeninX,Y
    CSF1PO10,12
    D2S133817
    D3S135815,16
    D5S81812,13
    D7S82010,11
    D8S117911,12
    D13S31710
    D16S53911
    D18S5114,16
    D19S43314,15
    D21S1128,29
    FGA22,23
    Penta D9,13
    Penta E7 (PubMed=25877200)
    7,19 (DSMZ)
    TH019,9.3
    TPOX8,9
    vWA17

    Run an STR similarity search on this cell line
    Web pageshttps://tcpaportal.org/mclp/
    Publications

    PubMed=1572647; DOI=10.1016/0888-7543(92)90303-A
    Szepetowski P., Simon M.-P., Grosgeorge J., Huebner K., Bastard C., Evans G.A., Tsujimoto Y., Birnbaum D., Theillet C., Gaudray P.
    Localization of 11q13 loci with respect to regional chromosomal breakpoints.
    Genomics 12:738-744(1992)

    PubMed=7504521; DOI=10.1002/gcc.2870080204
    Raynaud S.D., Bekri S., Leroux D., Grosgeorge J., Klein B., Bastard C., Gaudray P., Simon M.-P.
    Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B-cell malignancies.
    Genes Chromosomes Cancer 8:80-87(1993)

    PubMed=8558920
    Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M., Quentmeier H., Drexler H.G.
    The (2;5)(p23;q35) translocation in cell lines derived from malignant lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.
    Leukemia 10:142-149(1996)

    PubMed=14973505; DOI=10.1038/sj.leu.2403315
    Prod'homme T., Drenou B., De Ruyffelaere C., Barbieri G., Wiszniewski W., Bastard C., Charron D., Alcaide-Loridan C.
    Defective class II transactivator expression in a B lymphoma cell line.
    Leukemia 18:832-840(2004)

    PubMed=15126345; DOI=10.1158/0008-5472.CAN-03-3773
    Ota A., Tagawa H., Karnan S., Tsuzuki S., Karpas A., Kira S., Yoshida Y., Seto M.
    Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma.
    Cancer Res. 64:3087-3095(2004)

    PubMed=16448697; DOI=10.1016/j.leukres.2005.11.013
    Camps J., Salaverria I., Garcia M.J., Prat E., Bea S., Pole J.C.M., Hernandez L., Del Rey J., Cigudosa J.C., Bernues M., Caldas C., Colomer D., Miro R., Campo E.
    Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines.
    Leuk. Res. 30:923-934(2006)

    PubMed=16960149; DOI=10.1182/blood-2006-06-026500
    Mestre-Escorihuela C., Rubio-Moscardo F., Richter J.A., Siebert R., Climent J., Fresquet V., Beltran E., Agirre X., Marugan I., Marin M., Rosenwald A., Sugimoto K.-j., Wheat L.M., Karran E.L., Garcia J.F., Sanchez-Verde L., Prosper F., Staudt L.M., Pinkel D., Dyer M.J.S., Martinez-Climent J.A.
    Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
    Blood 109:271-280(2007)

    PubMed=17332242; DOI=10.1182/blood-2006-11-057208
    Pinyol M., Bea S., Pla L., Ribrag V., Bosq J., Rosenwald A., Campo E., Jares P.
    Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis.
    Blood 109:5422-5429(2007)

    PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
    Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
    A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
    Cancer Res. 70:2158-2164(2010)

    PubMed=21746927; DOI=10.1073/pnas.1018941108
    Beltran E., Fresquet V., Martinez-Useros J., Richter-Larrea J.A., Sagardoy A., Sesma I., Almada L.L., Montes-Moreno S., Siebert R., Gesk S., Calasanz M.J., Malumbres R., Rieger M., Prosper F., Lossos I.S., Piris M.A., Fernandez-Zapico M.E., Martinez-Climent J.A.
    A cyclin-D1 interaction with BAX underlies its oncogenic role and potential as a therapeutic target in mantle cell lymphoma.
    Proc. Natl. Acad. Sci. U.S.A. 108:12461-12466(2011)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=24362935; DOI=10.1038/nm.3435
    Rahal R., Frick M., Romero R., Korn J.M., Kridel R., Chan F.C., Meissner B., Bhang H.-E.C., Ruddy D., Kauffmann A., Farsidjani A., Derti A., Rakiec D., Naylor T., Pfister E., Kovats S., Kim S., Dietze K., Dorken B., Steidl C., Tzankov A., Hummel M., Monahan J., Morrissey M.P., Fritsch C., Sellers W.R., Cooke V.G., Gascoyne R.D., Lenz G., Stegmeier F.
    Pharmacological and genomic profiling identifies NF-kappaB-targeted treatment strategies for mantle cell lymphoma.
    Nat. Med. 20:87-92(2014)

    PubMed=25960936; DOI=10.4161/21624011.2014.954893
    Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.
    A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.
    OncoImmunology 3:e954893.1-e954893.12(2014)

    PubMed=25315077; DOI=10.3109/10428194.2014.970548
    Fogli L.K., Williams M.E., Connors J.M., Reid Y.A., Brown K., O'Connor O.A.
    Development and characterization of a Mantle Cell Lymphoma Cell Bank in the American Type Culture Collection.
    Leuk. Lymphoma 56:2114-2122(2015)

    PubMed=25355872; DOI=10.1128/JVI.02570-14
    Cao S.-B., Strong M.J., Wang X., Moss W.N., Concha M., Lin Z., O'Grady T., Baddoo M., Fewell C., Renne R., Flemington E.K.
    High-throughput RNA sequencing-based virome analysis of 50 lymphoma cell lines from the Cancer Cell Line Encyclopedia project.
    J. Virol. 89:713-729(2015)

    PubMed=25485619; DOI=10.1038/nbt.3080
    Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.
    A comprehensive transcriptional portrait of human cancer cell lines.
    Nat. Biotechnol. 33:306-312(2015)

    PubMed=25688540; DOI=10.1002/cyto.a.22643
    Maiga S., Brosseau C., Descamps G., Dousset C., Gomez-Bougie P., Chiron D., Menoret E., Kervoelen C., Vie H., Cesbron A., Moreau-Aubry A., Amiot M., Pellat-Deceunynck C.
    A simple flow cytometry-based barcode for routine authentication of multiple myeloma and mantle cell lymphoma cell lines.
    Cytometry A 87:285-288(2015)

    PubMed=25877200; DOI=10.1038/nature14397
    Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.
    A resource for cell line authentication, annotation and quality control.
    Nature 520:307-311(2015)

    PubMed=26589293; DOI=10.1186/s13073-015-0240-5
    Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
    TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
    Genome Med. 7:118.1-118.7(2015)

    PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
    Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
    Characterization of human cancer cell lines by reverse-phase protein arrays.
    Cancer Cell 31:225-239(2017)

    PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004
    Pham L.V., Huang S.-J., Zhang H., Zhang J., Bell T., Zhou S.-H., Pogue E., Ding Z.-Y., Lam L., Westin J., Davis R.E., Young K.H., Medeiros L.J., Ford R.J. Jr., Nomie K., Zhang L., Wang M.
    Strategic therapeutic targeting to overcome venetoclax resistance in aggressive B-cell lymphomas.
    Clin. Cancer Res. 24:3967-3980(2018)

    PubMed=30285677; DOI=10.1186/s12885-018-4840-5
    Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
    Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
    BMC Cancer 18:940.1-940.13(2018)

    PubMed=30629668; DOI=10.1371/journal.pone.0210404
    Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
    Screening human cell lines for viral infections applying RNA-Seq data analysis.
    PLoS ONE 14:E0210404-E0210404(2019)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=31160637; DOI=10.1038/s41598-019-44491-x
    Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
    The LL-100 panel: 100 cell lines for blood cancer studies.
    Sci. Rep. 9:8218-8218(2019)

    PubMed=31978347; DOI=10.1016/j.cell.2019.12.023
    Nusinow D.P., Szpyt J., Ghandi M., Rose C.M., McDonald E.R. III, Kalocsay M., Jane-Valbuena J., Gelfand E.T., Schweppe D.K., Jedrychowski M.P., Golji J., Porter D.A., Rejtar T., Wang Y.K., Kryukov G.V., Stegmeier F., Erickson B.K., Garraway L.A., Sellers W.R., Gygi S.P.
    Quantitative proteomics of the Cancer Cell Line Encyclopedia.
    Cell 180:387-402.e16(2020)

    Cross-references
    Cell line collections (Providers)ATCC; CRL-3004
    DSMZ; ACC-584
    IZSLER; BS TCL 227
    Cell line databases/resourcesCLO; CLO_0037056
    cancercelllines; CVCL_1884
    Cell_Model_Passport; SIDM01773
    DepMap; ACH-000068
    DSMZCellDive; ACC-584
    IGRhCellID; REC1
    LINCS_LDP; LCL-1123
    Anatomy/cell type resourcesBTO; BTO:0003558
    Biological sample resourcesBioSample; SAMN01821592
    BioSample; SAMN01821658
    BioSample; SAMN03471664
    BioSample; SAMN10989553
    Chemistry resourcesChEMBL-Cells; CHEMBL4482987
    ChEMBL-Targets; CHEMBL4483266
    PharmacoDB; REC1_1298_2019
    PubChem_Cell_line; CVCL_1884
    Encyclopedic resourcesWikidata; Q54949572
    Experimental variables resourcesEFO; EFO_0002317
    Gene expression databasesArrayExpress; E-MTAB-38
    ArrayExpress; E-MTAB-2706
    ArrayExpress; E-MTAB-2770
    ArrayExpress; E-MTAB-7721
    ArrayExpress; E-MTAB-7722
    GEO; GSM95565
    GEO; GSM95566
    GEO; GSM95570
    GEO; GSM104462
    GEO; GSM104463
    GEO; GSM115804
    GEO; GSM155072
    GEO; GSM155073
    GEO; GSM155074
    GEO; GSM629498
    GEO; GSM629499
    GEO; GSM887529
    GEO; GSM888611
    GEO; GSM1266771
    GEO; GSM1266772
    GEO; GSM2322622
    GEO; GSM3150255
    Polymorphism and mutation databasesCosmic; 1047111
    Cosmic; 1086341
    Cosmic; 1291033
    Cosmic; 2088020
    Cosmic; 2296993
    Cosmic; 2756235
    IARC_TP53; 25018
    IARC_TP53; 30218
    LiGeA; CCLE_530
    Progenetix; CVCL_1884
    Proteomic databasesPRIDE; PXD012087
    Sequence databasesEGA; EGAS00001000610
    EGA; EGAS00001002554
    Entry history
    Entry creation04-Apr-2012
    Last entry update05-Oct-2023
    Version number36

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