• NB4人急性早幼粒白血病细胞(STR鉴定正确)

    价 格😢:¥1800

    期 货:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号🅿️:BTCC-1118

    产地:中国

    套 餐🔎:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameNB4
    SynonymsNB-4; NB.4
    AccessionBTCC-1118
    Resource Identification InitiativeTo cite this cell line use: NB4 (BTCC-1118)
    CommentsGroup: Patented cell line.
    Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: COSMIC cell lines project.
    Part of: ENCODE project common cell types; tier 3.
    Part of: LL-100 blood cancer cell line panel.
    Registration: International Depositary Authority, Deutsche Sammlung von Mikroorganismen und Zellkulturen (DSMZ); ACC-2030.
    Registration: International Depositary Authority, Pasteur Institute Collection Nationale de Cultures de Micro-organismes (CNCM); I-1045.
    Population: Caucasian.
    Doubling time: 36-40 hours (PubMed=1995093); 30 hours (PubMed=25984343); ~35-45 hours (DSMZ=ACC-207).
    Microsatellite instability: Stable (MSS) (Sanger).
    Omics: Cell surface proteome.
    Omics: CTCF ChIP-seq epigenome analysis.
    Omics: H3K4me3 ChIP-seq epigenome analysis.
    Omics: Deep antibody staining analysis.
    Omics: Deep exome analysis.
    Omics: Deep quantitative proteome analysis.
    Omics: DNA methylation analysis.
    Omics: shRNA library screening.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
    Sequence variations
    • Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (PubMed=12353268; PubMed=15843827).
    • Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (Cosmic-CLP; DepMap).
    • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (Cosmic-CLP).
    HLA typingSource: PubMed=26589293
    Class I
    HLA-AA*11:01,11:01
    HLA-BB*35:01,40:01
    HLA-CC*03:04,04:01

    Source: CLS=300299
    Class I
    HLA-AA*11:01:01
    HLA-BB*35:01:01,40:01:02
    HLA-CC*03:04:01,04:01:01
    Class II
    HLA-DPDPB1*01:01:01,04:01:01
    HLA-DQDQA1*01:01,03:01:01

    DQB1*03:02,05:01:01
    HLA-DRDRB1*01:01:01,04:04:01

    Source: DSMZCellDive=ACC-207
    Class I
    HLA-AA*11:01:01,11:01:01
    HLA-BB*35:01:01,40:01:02
    HLA-CC*03:04:01,04:01:01
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African3.99
    Native American0
    East Asian, North4.75
    East Asian, South0
    South Asian0
    European, North49.28
    European, South41.98
    DiseaseAcute promyelocytic leukemia with PML-RARA (NCIt: C3182)
    Acute promyelocytic leukemia (ORDO: Orphanet_520)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyChildren:



    CVCL_VV77 (NB4-A1)CVCL_U080 (NB4-AsR)CVCL_VV78 (NB4-B1)
    CVCL_VV79 (NB4-D5)CVCL_U085 (NB4-DR1)CVCL_8811 (NB4-LR1)
    CVCL_U086 (NB4-S1)CVCL_U083 (NB4.007/6)CVCL_U084 (NB4.306)
    CVCL_U112 (NB4.437r)CVCL_U082 (NB4/As)CVCL_IY15 (NB4R)
    Sex of cellFemale
    Age at sampling23Y
    CategoryCancer cell line
    STR profileSource(s): CLS; Cosmic-CLP; DSMZ; PubMed=25877200

    Markers:
    AmelogeninX
    CSF1PO11,12
    D2S133820,25
    D3S135815,17
    D5S81813
    D7S82010,13
    D8S117910,14
    D13S31711,12
    D16S5399
    D18S5112,14
    D19S43315
    D21S1128,33.2
    FGA21,22
    Penta D10,13
    Penta E7,13
    TH017,9.3
    TPOX8,11
    vWA16,19

    Run an STR similarity search on this cell line
    Web pageshttps://www.proteinatlas.org/learn/cellines
    http://genome.ucsc.edu/ENCODE/protocols/cell/human/NB4_protocol.pdf
    Publications

    PubMed=1995093; DOI=10.1182/blood.V77.5.1080.1080
    Lanotte M., Martin-Thouvenin V., Najman S., Balerini P., Valensi F., Berger R.
    NB4, a maturation inducible cell line with t(15;17) marker isolated from a human acute promyelocytic leukemia (M3).
    Blood 77:1080-1086(1991)

    PubMed=1453773
    Duprez E., Ruchaud S., Houge G., Martin-Thouvenin V., Valensi F., Kastner P., Berger R., Lanotte M.
    A retinoid acid 'resistant' t(15;17) acute promyelocytic leukemia cell line: isolation, morphological, immunological, and molecular features.
    Leukemia 6:1281-1287(1992)

    PubMed=7630193
    Bruel A., Benoit G., De Nay D., Brown S., Lanotte M.
    Distinct apoptotic responses in maturation sensitive and resistant t(15;17) acute promyelocytic leukemia NB4 cells. 9-cis retinoic acid induces apoptosis independent of maturation and Bcl-2 expression.
    Leukemia 9:1173-1184(1995)

    Patent=US5589345
    Lanotte M., Berger R.
    Cultures of permanent lines of human promyelocytic cells and their uses for the screening of molecules utilizable in particular in the treatment of leukemias.
    Patent number US5589345, 31-Dec-1996

    PubMed=9737686; DOI=10.1038/sj.leu.2401112
    Zhang W., Ohnishi K., Shigeno K., Fujisawa S., Naito K., Nakamura S., Takeshita K., Takeshita A., Ohno R.
    The induction of apoptosis and cell cycle arrest by arsenic trioxide in lymphoid neoplasms.
    Leukemia 12:1383-1391(1998)

    DOI=10.1016/B978-0-12-221970-2.50457-5
    Drexler H.G.
    The leukemia-lymphoma cell line factsbook.
    (In) ISBN 9780122219702; pp.1-733; Academic Press; London (2001)

    PubMed=11704857; DOI=10.1038/sj.onc.1204863
    Roussel M.J.S., Lanotte M.
    Maturation sensitive and resistant t(15;17) NB4 cell lines as tools for APL physiopathology: nomenclature of cells and repertory of their known genetic alterations and phenotypes.
    Oncogene 20:7287-7291(2001)

    PubMed=12353268; DOI=10.1002/gcc.10117
    Mozziconacci M.-J., Rosenauer A., Restouin A., Fanelli M., Shao W.-L., Fernandez F., Toiron Y., Viscardi J., Gambacorti-Passerini C., Miller W.H. Jr., Lafage-Pochitaloff M.
    Molecular cytogenetics of the acute promyelocytic leukemia-derived cell line NB4 and of four all-trans retinoic acid-resistant subclones.
    Genes Chromosomes Cancer 35:261-270(2002)

    PubMed=14504097; DOI=10.1182/blood-2003-02-0418
    Taketani T., Taki T., Sugita K., Furuichi Y., Ishii E., Hanada R., Tsuchida M., Sugita K., Ida K., Hayashi Y.
    FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy.
    Blood 103:1085-1088(2004)

    PubMed=15843827; DOI=10.1038/sj.leu.2403749
    Andersson A., Eden P., Lindgren D., Nilsson J., Lassen C., Heldrup J., Fontes M., Borg A., Mitelman F., Johansson B., Hoglund M., Fioretos T.
    Gene expression profiling of leukemic cell lines reveals conserved molecular signatures among subtypes with specific genetic aberrations.
    Leukemia 19:1042-1050(2005)

    PubMed=16408098; DOI=10.1038/sj.leu.2404081
    Quentmeier H., MacLeod R.A.F., Zaborski M., Drexler H.G.
    JAK2 V617F tyrosine kinase mutation in cell lines derived from myeloproliferative disorders.
    Leukemia 20:471-476(2006)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=23325432; DOI=10.1101/gr.147942.112
    Varley K.E., Gertz J., Bowling K.M., Parker S.L., Reddy T.E., Pauli-Behn F., Cross M.K., Williams B.A., Stamatoyannopoulos J.A., Crawford G.E., Absher D.M., Wold B.J., Myers R.M.
    Dynamic DNA methylation across diverse human cell lines and tissues.
    Genome Res. 23:555-567(2013)

    PubMed=23955599; DOI=10.1038/ng.2731
    Kon A., Shih L.-Y., Minamino M., Sanada M., Shiraishi Y., Nagata Y., Yoshida K.-I., Okuno Y., Bando M., Nakato R., Ishikawa S., Sato-Otsubo A., Nagae G., Nishimoto A., Haferlach C., Nowak D., Sato Y., Alpermann T., Nagasaki M., Shimamura T., Tanaka H., Chiba K., Yamamoto R., Yamaguchi T., Otsu M., Obara N., Sakata-Yanagimoto M., Nakamaki T., Ishiyama K., Nolte F., Hofmann W.-K., Miyawaki S., Chiba S., Mori H., Nakauchi H., Koeffler H.P., Aburatani H., Haferlach T., Shirahige K., Miyano S., Ogawa S.
    Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms.
    Nat. Genet. 45:1232-1237(2013)

    PubMed=25984343; DOI=10.1038/sdata.2014.35
    Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S., East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H., Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M., Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S., Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D., Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C., Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P., Golub T.R., Root D.E., Hahn W.C.
    Parallel genome-scale loss of function screens in 216 cancer cell lines for the identification of context-specific genetic dependencies.
    Sci. Data 1:140035-140035(2014)

    PubMed=25894527; DOI=10.1371/journal.pone.0121314
    Bausch-Fluck D., Hofmann A., Bock T., Frei A.P., Cerciello F., Jacobs A., Moest H., Omasits U., Gundry R.L., Yoon C., Schiess R., Schmidt A., Mirkowska P., Hartlova A.S., Van Eyk J.E., Bourquin J.-P., Aebersold R., Boheler K.R., Zandstra P.W., Wollscheid B.
    A mass spectrometric-derived cell surface protein atlas.
    PLoS ONE 10:E0121314-E0121314(2015)

    PubMed=26589293; DOI=10.1186/s13073-015-0240-5
    Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
    TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
    Genome Med. 7:118.1-118.7(2015)

    PubMed=27397505; DOI=10.1016/j.cell.2016.06.017
    Iorio F., Knijnenburg T.A., Vis D.J., Bignell G.R., Menden M.P., Schubert M., Aben N., Goncalves E., Barthorpe S., Lightfoot H., Cokelaer T., Greninger P., van Dyk E., Chang H., de Silva H., Heyn H., Deng X.-M., Egan R.K., Liu Q.-S., Mironenko T., Mitropoulos X., Richardson L., Wang J.-H., Zhang T.-H., Moran S., Sayols S., Soleimani M., Tamborero D., Lopez-Bigas N., Ross-Macdonald P., Esteller M., Gray N.S., Haber D.A., Stratton M.R., Benes C.H., Wessels L.F.A., Saez-Rodriguez J., McDermott U., Garnett M.J.
    A landscape of pharmacogenomic interactions in cancer.
    Cell 166:740-754(2016)

    PubMed=30285677; DOI=10.1186/s12885-018-4840-5
    Tan K.-T., Ding L.-W., Sun Q.-Y., Lao Z.-T., Chien W., Ren X., Xiao J.-F., Loh X.-Y., Xu L., Lill M., Mayakonda A., Lin D.-C., Yang H., Koeffler H.P.
    Profiling the B/T cell receptor repertoire of lymphocyte derived cell lines.
    BMC Cancer 18:940.1-940.13(2018)

    PubMed=30629668; DOI=10.1371/journal.pone.0210404
    Uphoff C.C., Pommerenke C., Denkmann S.A., Drexler H.G.
    Screening human cell lines for viral infections applying RNA-Seq data analysis.
    PLoS ONE 14:E0210404-E0210404(2019)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    PubMed=31160637; DOI=10.1038/s41598-019-44491-x
    Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M., MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.
    The LL-100 panel: 100 cell lines for blood cancer studies.
    Sci. Rep. 9:8218-8218(2019)

    PubMed=35839778; DOI=10.1016/j.ccell.2022.06.010
    Goncalves E., Poulos R.C., Cai Z.-X., Barthorpe S., Manda S.S., Lucas N., Beck A., Bucio-Noble D., Dausmann M., Hall C., Hecker M., Koh J., Lightfoot H., Mahboob S., Mali I., Morris J., Richardson L., Seneviratne A.J., Shepherd R., Sykes E., Thomas F., Valentini S., Williams S.G., Wu Y.-X., Xavier D., MacKenzie K.L., Hains P.G., Tully B., Robinson P.J., Zhong Q., Garnett M.J., Reddel R.R.
    Pan-cancer proteomic map of 949 human cell lines.
    Cancer Cell 40:835-849.e8(2022)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0007947
    MCCL; MCC:0000350
    CLDB; cl3643
    Cell_Model_Passport; SIDM00428
    Cosmic-CLP; 1323913
    DepMap; ACH-000294
    DSMZCellDive; ACC-207
    LINCS_LDP; LCL-1084
    Lonza; 749
    Anatomy/cell type resourcesBTO; BTO:0002136
    Biological sample resourcesBioSample; SAMN03470835
    BioSample; SAMN10988571
    ENCODE; ENCBS032SIL
    ENCODE; ENCBS259AAA
    ENCODE; ENCBS390ENC
    Cell line collections (Providers)CLS; 300299
    DSMZ; ACC-207
    NCBI_Iran; C515
    Chemistry resourcesChEMBL-Cells; CHEMBL3308423
    ChEMBL-Targets; CHEMBL614188
    GDSC; 1323913
    PharmacoDB; NB4_990_2019
    PubChem_Cell_line; CVCL_0005
    Encyclopedic resourcesWikidata; Q54907527
    Experimental variables resourcesEFO; EFO_0002798

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