• L-02(HL-7702)人正常肝细胞

    价 格:¥1800

    期 货💌:现货(冻存管发2支)

    保藏中心:BTCC

    资源编号🙂‍↕️🦹🏻:BTCC-1093

    产地:中国

    套 餐:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameL-02
    SynonymsL02; LO2; HL-7702; HL7702; Liver-02; Human Liver-7702
    AccessionBTCC-1093
    Resource Identification InitiativeTo cite this cell line use: L-02 (BTCC-1093)
    CommentsProblematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=26116706). Originally thought to originate from a normal fetal liver.
    Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00575.
    Population: African American.
    Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
    Omics: Proteome analysis.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
    DiseaseHuman papillomavirus-related endocervical adenocarcinoma (NCIt: C27677)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyParent: CVCL_0030 (HeLa)
    Children:

    CVCL_WN40 (HL-7702BaPT)
    Sex of cellFemale
    Age at sampling30Y6M
    CategoryCancer cell line
    STR profileSource(s): PubMed=26116706

    Markers:
    AmelogeninX
    CSF1PO10
    D3S135815,18
    D5S81811,12
    D7S82012
    D8S117912
    D13S31713.3
    D16S5399,10
    D18S5116
    D21S1127,28
    FGA18,21
    Penta D8,15
    Penta E7,17
    TH017
    TPOX12
    vWA16,18

    Run an STR similarity search on this cell line
    Web pageshttps://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
    http://www.roche-applied-science.com/wcsstore/RASCatalogAssetStore/Articles/CustomerProtocol_X-tremeGENE%20HP_L02.pdf
    https://www.quora.com/How-does-the-L-02-cell-line-compare-with-the-TAMH-cell-line-How-closely-do-these-two-cell-lines-resemble-actual-human-hepatocytes
    Publications

    PubMed=23498809; DOI=10.1016/j.transproceed.2012.09.121
    Hu X., Yang T., Li C., Zhang L., Li M., Huang W., Zhou P.
    Human fetal hepatocyte line, L-02, exhibits good liver function in vitro and in an acute liver failure model.
    Transplant. Proc. 45:695-700(2013)

    PubMed=23505090; DOI=10.1002/hep.26402
    Wang K., Lim H.Y., Shi S., Lee J., Deng S., Xie T., Zhu Z., Wang Y., Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J.
    Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
    Hepatology 58:706-717(2013)

    PubMed=26116706; DOI=10.1096/fj.14-266718
    Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.
    Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
    FASEB J. 29:4268-4272(2015)

    PubMed=26143199; DOI=10.1016/j.jhazmat.2015.06.031
    Cui R., Zhang H.-X., Guo X.-J., Cui Q.-Q., Wang J.-S., Dai J.-Y.
    Proteomic analysis of cell proliferation in a human hepatic cell line (HL-7702) induced by perfluorooctane sulfonate using iTRAQ.
    J. Hazard. Mater. 299:361-370(2015)

    PubMed=27027780; DOI=10.1007/s10565-016-9316-2
    Wu Y., Geng X.-C., Wang J.-F., Miao Y.-F., Lu Y.-L., Li B.
    The HepaRG cell line, a superior in vitro model to L-02, HepG2 and hiHeps cell lines for assessing drug-induced liver injury.
    Cell Biol. Toxicol. 32:37-59(2016)

    Cross-references
    Cell line databases/resourcesTOKU-E; 3606
    Anatomy/cell type resourcesBTO; BTO:0005965
    Cell line collections (Providers)KCB; KCB 200511YJ
    Chemistry resourcesChEMBL-Cells; CHEMBL4295475
    ChEMBL-Targets; CHEMBL4296457
    PubChem_Cell_line; CVCL_6926
    Encyclopedic resourcesWikidata; Q54900854
    Gene expression databasesGEO; GSM936770

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