• HEC-1-B人子宫内膜癌细胞(STR鉴定正确)

    价 格🧘🏽‍♂️:¥1800

    期 货🛬:现货(冻存管发2支)

    保藏中心🦸🏿‍♀️:BTCC

    资源编号:BTCC-1062

    产地:中国

    套 餐:

    T25/复苏细胞 无血清冻存液 专用完全培养基500ml 南美特级胎牛血清500ml

    详细资料说明书下载质检报告(COA)

    Cell line nameHEC-1-B
    SynonymsHec-1-B; HEC-1B; Hec-1b; HEC1-B; HEC1B; Hec1B
    AccessionBTCC-1062
    Resource Identification InitiativeTo cite this cell line use: HEC-1-B (BTCC-1062)
    CommentsPart of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
    Part of: MD Anderson Cell Lines Project.
    Population: Japanese.
    Microsatellite instability: Instable (MSI) (PubMed=31068700).
    Omics: Array-based CGH.
    Omics: Deep exome analysis.
    Omics: Protein expression by reverse-phase protein arrays.
    Omics: SNP array analysis.
    Omics: Transcriptome analysis by microarray.
    Omics: Transcriptome analysis by RNAseq.
    Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
    Sequence variations
    • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (DepMap).
    • Mutation; HGNC; 7329; MSH6; Simple; p.Phe1088Serfs*2 (c.3261delC); ClinVar=VCV000089363; Zygosity=Heterozygous (DepMap).
    • Mutation; HGNC; 7329; MSH6; Simple; c.4001+1G>T; ClinVar=VCV001736936; Zygosity=Heterozygous; Note=Splice donor mutation (DepMap).
    • Mutation; HGNC; 9122; PMS2; Simple; p.Arg802Ter (c.2404C>T); ClinVar=VCV000009237; Zygosity=Heterozygous (DepMap).
    • Mutation; HGNC; 9588; PTEN; None_reported; -; Zygosity=- (PubMed=20944090).
    • Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (DepMap).
    Genome ancestrySource: PubMed=30894373

    Origin% genome


    African0
    Native American0.76
    East Asian, North92.48
    East Asian, South6.76
    South Asian0
    European, North0
    European, South0
    DiseaseEndometrial adenocarcinoma (NCIt: C7359)
    Species of originHomo sapiens (Human) (NCBI Taxonomy: 9606)
    HierarchyParent: CVCL_0293 (HEC-1-A)
    Children:



    CVCL_XC84 (HEC-1-B-Cas9-580)CVCL_XC85 (HEC-1-B-Cas9-581)CVCL_XC86 (HEC-1-B-Cas9-582)
    CVCL_XC87 (HEC-1-B-Cas9-583)CVCL_XC88 (HEC-1-B-Cas9-584)CVCL_XC89 (HEC-1-B-Cas9-585)
    CVCL_XC90 (HEC-1-B-Cas9-586)CVCL_XC91 (HEC-1-B-Cas9-587)CVCL_XC92 (HEC-1-B-Cas9-588)
    CVCL_XC93 (HEC-1-B-Cas9-589)CVCL_XC94 (HEC-1-B-Cas9-590)CVCL_XC95 (HEC-1-B-Cas9-591)
    CVCL_XC96 (HEC-1-B-Cas9-592)CVCL_YJ46 (HEC-1BE)
    Sex of cellFemale
    Age at sampling71Y
    CategoryCancer cell line
    STR profileSource(s): ATCC; CCRID; JCRB; PubMed=25877200

    Markers:
    AmelogeninX
    CSF1PO10,12
    D2S133818,19
    D3S135815
    D5S81811,13
    D7S8209,11
    D8S117913,14
    D13S31711 (JCRB; PubMed=25877200)
    11,16 (ATCC; CCRID)
    D16S53911,12
    D18S5116,20
    D19S43313
    D21S1130,31
    FGA21
    Penta D9,13
    Penta E11
    TH016 (PubMed=25877200)
    6,7 (ATCC; CCRID; JCRB)
    TPOX8,11
    vWA18

    Run an STR similarity search on this cell line
    Web pageshttps://tcpaportal.org/mclp/
    Publications

    PubMed=4678779
    Kuramoto H.
    Studies of the growth and cytogenetic properties of human endometrial adenocarcinoma in culture and its development into an established line.
    Acta Obstet. Gynaecol. Jpn. 19:47-58(1972)

    PubMed=327080; DOI=10.1093/jnci/59.1.221
    Fogh J., Fogh J.M., Orfeo T.
    One hundred and twenty-seven cultured human tumor cell lines producing tumors in nude mice.
    J. Natl. Cancer Inst. 59:221-226(1977)

    PubMed=833871; DOI=10.1093/jnci/58.2.209
    Fogh J., Wright W.C., Loveless J.D.
    Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
    J. Natl. Cancer Inst. 58:209-214(1977)

    PubMed=6163305
    Sekiya S., Takamizawa H.
    Effect of anticancer drugs on in vitro survival of cell lines derived from various gynecologic tumors.
    Nihon Sanka Fujinka Gakkai Zasshi 33:373-376(1981)

    PubMed=6174649
    Sekiya S., Kawata M., Inaba N., Takamizawa H.
    Studies on marker substances in cell lines derived from various human gynecologic tumors.
    Nihon Sanka Fujinka Gakkai Zasshi 34:37-42(1982)

    PubMed=6220172
    Dracopoli N.C., Fogh J.
    Polymorphic enzyme analysis of cultured human tumor cell lines.
    J. Natl. Cancer Inst. 70:469-476(1983)

    PubMed=3518877; DOI=10.3109/07357908609038260
    Fogh J.
    Human tumor lines for cancer research.
    Cancer Invest. 4:157-184(1986)

    PubMed=12227503; DOI=10.1111/j.1749-0774.2002.tb00103.x
    Kurarmoto H., Hamano M., Imai M.
    HEC-1 cells.
    Hum. Cell 15:81-95(2002)

    DOI=10.1007/978-4-431-53981-0_1
    Kuramoto H., Hamano M., Imai M., Fujisawa T., Kamata Y., Arai T., Kawaguchi M.
    HEC-1 cells: establishment of an in vitro experimental system in endometrial carcinoma.
    (In) Cell and molecular biology of endometrial carcinoma; Kuramoto H., Nishida M. (eds.); pp.3-34; Springer; Tokyo (2003)

    PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458
    Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P., Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J., Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C., Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J., Haber D.A.
    A genome-wide screen for microdeletions reveals disruption of polarity complex genes in diverse human cancers.
    Cancer Res. 70:2158-2164(2010)

    PubMed=20218740; DOI=10.1177/153303461000900207
    Wang Y.-M., Yang D., Cogdell D., Hu L.-M., Xue F.-X., Broaddus R., Zhang W.
    Genomic characterization of gene copy-number aberrations in endometrial carcinoma cell lines derived from endometrioid-type endometrial adenocarcinoma.
    Technol. Cancer Res. Treat. 9:179-189(2010)

    PubMed=20944090; DOI=10.1126/scitranslmed.3001538
    Dedes K.J., Wetterskog D., Mendes-Pereira A.M., Natrajan R., Lambros M.B., Geyer F.C., Vatcheva R., Savage K., Mackay A., Lord C.J., Ashworth A., Reis-Filho J.S.
    PTEN deficiency in endometrioid endometrial adenocarcinomas predicts sensitivity to PARP inhibitors.
    Sci. Transl. Med. 2:53ra75.1-53ra75.8(2010)

    PubMed=22460905; DOI=10.1038/nature11003
    Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
    The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    Nature 483:603-607(2012)

    PubMed=22710073; DOI=10.1016/j.ygyno.2012.06.017
    Korch C.T., Spillman M.A., Jackson T.A., Jacobsen B.M., Murphy S.K., Lessey B.A., Jordan V.C., Bradford A.P.
    DNA profiling analysis of endometrial and ovarian cell lines reveals misidentification, redundancy and contamination.
    Gynecol. Oncol. 127:241-248(2012)

    PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
    Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
    Characterization of human cancer cell lines by reverse-phase protein arrays.
    Cancer Cell 31:225-239(2017)

    PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
    Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
    An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
    Cancer Res. 79:1263-1273(2019)

    PubMed=31068700; DOI=10.1038/s41586-019-1186-3
    Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
    Next-generation characterization of the Cancer Cell Line Encyclopedia.
    Nature 569:503-508(2019)

    Cross-references
    Cell line databases/resourcesCLO; CLO_0003675
    MCCL; MCC:0000184
    CLDB; cl1582
    CCRID; 1101HUM-PUMC000105
    CCRID; 3101HUMTCHu115
    CCRID; 4201HUM-CCTCC00129
    Cell_Model_Passport; SIDM01241
    DepMap; ACH-000941
    IGRhCellID; HEC1B
    Anatomy/cell type resourcesBTO; BTO:0003038
    Biological sample resourcesBioSample; SAMN03471094
    BioSample; SAMN03472427
    BioSample; SAMN03473077
    BioSample; SAMN10987737
    Cell line collections (Providers)ATCC; HTB-113
    CCTCC; GDC0129
    CLS; 305095
    JCRB; JCRB1193
    JCRB; NIHS0480 - Discontinued
    KCB; KCB 200551YJ
    Chemistry resourcesChEMBL-Cells; CHEMBL3308662
    ChEMBL-Targets; CHEMBL614817
    PharmacoDB; HEC1B_532_2019
    PubChem_Cell_line; CVCL_0294
    Encyclopedic resourcesWikidata; Q54882253
    Experimental variables resourcesEFO; EFO_0002192

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